Phenytoin use in elderly

Background: Phenytoin (PHT) dosing regimens are often determined based on experience in those aged ( 65 years rather than in those aged ≥65 years.

Phenytoin, sold under the brand name Dilantin among others, is an anti-seizure medication Elderly: May show earlier signs of toxicity Due to decreased drug concentrations during pregnancy, dose of phenytoin may need to be increased. Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.

Neurology 2008; 71:38. Many neurologists advocate the use of the newer AEDs (eg, In one study of elderly nursing home residents, phenytoin levels were highly. With regard to the latter we looked carefully at the methods that have been used to characterise the disposition kinetics of phenytoin in general, and in orlistat facmed elderly.

Phenytoin Use In Elderly

Age Ageing. 1977 Aug;6(3):133-7. Phenytoin dosage in the elderly. Lambie DC, Caird FI. Measurement of serum-phenytoin concentrations in 17 elderly patients. Inappropriate AED therapy. Hence, the standard of care for older patients with epilepsy should be reevaluated, although the vast use of phenytoin in this.

Clearance' of free phenytoin is reduced in the elderly. However, the to dose, in elderly patients but free 'apparent clearance' was not. Loading dose: Some authorities have advocated use of an oral loading dose of phenytoin in adults who require rapid steady-state serum levels and where. In addition, this section of the meds to help with cymbalta withdrawal tends to use drugs more frequently, Phenytoin is probably the most widely used drug among the elderly due to the.

A loading dose of parenteral Dilantin should be injected slowly, not exceeding 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per. The goal of antiepileptic drug therapy is to control seizures but preserve quality of life Drugs for first-line monotherapy of seizures in elderly patients include carbamazepine, valproic acid, oxcarbazepine, gabapentin, and lamotrigine.

Learn about the causes, symptoms, diagnosis & treatment of Drug Therapy in the Elderly from the Professional Version of the Merck Manuals. The majority of elderly people with epilepsy have partial seizures with or without secondary The chronic use of phenytoin may worsen pre-existing peripheral.

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